MST® RESVERATROL: Support of Cellular Metabolism and Regulation of Aging Processes

MST® Resveratrol 60 capsules is a high-quality dietary supplement that you can buy in Germany and that is manufactured in Germany (MADE IN GERMANY). It contains 150 mg of pure trans-resveratrol, obtained from Japanese knotweed root extract (Japanese Knotweed Root Extract). This polyphenolic stilbenoid is the subject of intensive scientific research due to its key role in the activation of sirtuins (SIRT1) – enzymes involved in longevity and in the regulation of cellular energy pathways [1.2, 1.7]. The product provides a concentrated dose of the active isomeric form that is necessary for maintaining the proper function of the vascular system and metabolic balance.

In-Depth Look at Trans-Resveratrol and Japanese Knotweed

Resveratrol is a powerful natural polyphenol that belongs to the stilbenoid class. It exists in two isomeric forms – cis and trans – with trans-resveratrol being recognized as the biologically active form that has a proven effect on cellular processes [2.3].

Japanese Knotweed as a Source of Purity

Although resveratrol is mainly associated with red grapes and wine, the root extract of Japanese knotweed (Polygonum cuspidatum) is used to produce highly concentrated dietary supplements such as MST® [1.2, 3.4].

• High concentration: The root of Japanese knotweed is one of the most reliable natural sources and, under commercial extraction, provides a high concentration of trans-resveratrol (up to 98%) [3.1, 3.7].

• Traditional use: In traditional Asian medicine, Polygonum cuspidatum extract has historically been used to support cardiovascular and respiratory functions [1.4, 3.2].

The Advantage of the Trans Form

MST® Resveratrol provides 150 mg of pure trans-resveratrol. Choosing this form is crucial because its molecular structure ensures greater stability and efficacy when interacting with key target structures inside the cell that play a role in regulating cellular aging [1.3].

Fundamental Mechanisms of Action and SIRT1 Activation

The scientific community pays particular attention to resveratrol because of its unique ability to modulate fundamental signaling pathways associated with longevity and the resilience of cells to stress.

Activation of the “Longevity Regulators”

The key mechanism of action of trans-resveratrol is its function as a activator of sirtuin 1 (SIRT1) [1.2, 1.7].

• SIRT1 is a NAD+-dependent protein deacetylase that acts as a central metabolic regulator [1.2].

• Activation of SIRT1 by the ingredient trans-resveratrol mimics the effects of caloric restriction, thereby enhancing cell survival and their regenerative capacity [1.2].

• Through SIRT1 activation, resveratrol promotes the expression of antioxidant genes (e.g. superoxide dismutase, catalase) via the Nrf2/ARE pathway and strengthens cellular protection against oxidative damage [1.7].

Mitochondrial and Energy Function

SIRT1 activation also interacts with AMPK (AMP-activated protein kinase), which is critical for:

• Mitochondrial biogenesis: Stimulation of the formation of new mitochondria, which are the energy centers of the cell. This helps maintain a high energetic performance of cells, especially in muscle and nerve tissues [1.5].

• Metabolic flexibility: Contribution to improved glucose transport and lipid balance in cells [1.5, 3.3].

Influence of the Ingredient on Vascular and Metabolic Functions

Studies have shown that systematic intake of trans-resveratrol has a proven effect on the functional state of the circulatory system and on metabolic processes.

Support of the Vascular System

• Endothelial function: Trans-resveratrol helps regulate eNOS (endothelial nitric oxide synthase), which increases the bioavailability of nitric oxide (•NO). This in turn promotes vasodilation (widening of blood vessels) and helps maintain the elasticity of vessel walls [1.7, 2.3].

• Cardioprotective effect: Improved endothelial function helps reduce the risk of atherosclerotic plaque formation and platelet aggregation, which is important for maintaining adequate blood flow and proper function of the heart muscle [2.3].

• Blood pressure: Meta-analyses of clinical studies suggest that intake of trans-resveratrol in doses above 150 mg/day can help reduce systolic and diastolic blood pressure in individuals with metabolic disorders [2.2].

Metabolic Regulation

• Glycemic control: It has been found that trans-resveratrol in doses above 100 mg/day can exert a hypoglycemic effect [1.5, 3.4]. This is due to its ability to increase insulin sensitivity and protect pancreatic beta cells [3.2].

• Lipid profile: Clinical studies have observed that resveratrol intake helps reduce LDL cholesterol levels (the so-called “bad” cholesterol) [2.2, 3.4].

Advantages of the MST® Formulation and the 150 mg Dosage

MST® Resveratrol is a highly pure product that ensures precise dosing of the active ingredient.

• Critical dosage: Each capsule contains 150 mg of trans-resveratrol. This is the dose that has been defined in clinical studies as the threshold level for significant effects on vascular function and metabolic markers [2.2].

• Purity of the form: The use of Japanese knotweed root extract guarantees a high concentration of the trans isomer, which is crucial for SIRT1 activation and antioxidant protection [1.7].

• German quality (MADE IN GERMANY): Production in Germany guarantees compliance with strict European standards of quality and purity.

Detailed Overview of Ingredients and Dosage (per 1 Capsule – Daily Serving)

The MST® Resveratrol formulation contains minimal excipients, with the focus on the purity of the active substance.

Recommended Use for MST® Resveratrol

To achieve maximum effectiveness and consistency with research protocols, it is important to follow the recommended intake regimen.

Recommended dosage:

• Take 1 capsule daily.

  Intake regimen:

• The capsule should be taken daily with sufficient water.

  Important notes (in accordance with EU regulations):

1. The recommended daily intake must not be exceeded.

2. This product is a dietary supplement and should not be used as a substitute for a varied, balanced diet.

3. Consultation with a specialist: People taking medications, especially anticoagulants or blood pressure-regulating drugs, as well as pregnant or breastfeeding women, should consult a specialist before use.

4. Storage: Store in a cool, dry place out of the reach of small children.

Where to Buy MST® RESVERATROL: Availability in Germany and the EU

Purchase in the EU (European Union): MADE IN GERMANY

The MST® Resveratrol product, manufactured in Germany, is widely available through MST Nutrition’s distribution network in Europe. This guarantees premium quality and European service standards.

If you want to buy high-quality trans-resveratrol at the best prices in Europe, choose official MST® products.

MST® Resveratrol is available in all major EU countries, including:

• Germany: Berlin, Munich, Hamburg.

• Poland: Warsaw, Krakow, Gdańsk.

• France: Paris, Marseille, Lyon.

• Italy: Rome, Milan, Naples.

• Spain: Madrid, Barcelona, Valencia.

  For orders and detailed information, please visit the official German website of the manufacturer:

• Official manufacturer’s website: Resveratrol 60 Kapseln — Premium-Qualität

📚 Research Sources

[1.1] Resveratrol-like Compounds as SIRT1 Activators. ResearchGate, 2025.

[1.2] The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. PMC, 2019.

[1.3] Mechanism of Human SIRT1 Activation by Resveratrol. ResearchGate, 2005.

[1.4] Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases. ResearchGate, 2019.

[1.5] Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. NIH, 2023.

[1.7] Resveratrol-like Compounds as SIRT1 Activators. MDPI, 2022.

[2.2] Effect of Resveratrol on the Cardiovascular System. Encyclopedia.pub, 2021.

[2.3] Resveratrol and Cardiovascular Diseases. PMC, 2015.

[3.1] Bulk Polygonum Cuspidatum Extract (Trans-Resveratrol >20%). Ingredients Online.

[3.2] Polygonum cuspidatum – Knowledge and References. Taylor & Francis.

[3.3] Trans Resveratrol - Polygonum Cuspidatum. Hydra Longevity.

[3.4] A Comparative Evaluation of the Antioxidant Ability of Polygonum cuspidatum Extracts with That of Resveratrol Itself. MDPI, 2023.

[3.7] Polygonum Cuspidatum Extract 98% Trans Resveratrol. Phytochem International Inc.